What is SPRAVATO®
A different mechanism, for depression that hasn't responded to the usual ones.
SPRAVATO® is an FDA-approved prescription nasal spray for adults with treatment-resistant depression (TRD). Unlike traditional antidepressants that primarily target serotonin, SPRAVATO works through different pathways in the brain.
For treatment-resistant depression, SPRAVATO may be used alone or in combination with an oral antidepressant. Treatment is administered under direct psychiatric supervision in a certified healthcare setting.
Response to SPRAVATO® varies from person to person. Your symptoms and progress will be monitored throughout treatment to help determine the appropriate ongoing treatment schedule.
What is SPRAVATO®
What treatment-resistant depression means
Treatment-resistant depression occurs when depression symptoms continue despite adequate treatment with at least two different antidepressant medications.
You continue experiencing depression despite medication treatment
You've tried multiple antidepressants without sufficient improvement
Symptoms interfere with work, relationships, or daily life
You're seeking additional options under psychiatric supervision
Eligibility is determined through a comprehensive psychiatric evaluation, not a checklist — these are starting points for a conversation with our team.
What treatment looks like over time
The treatment schedule
Sessions are most frequent at the start and taper as your provider assesses your response.
Weeks 1–4
Induction
Twice-weekly treatment sessions, closely monitored.
Weeks 5–8
Tapering
Weekly sessions as your response is assessed.
Ongoing
Maintenance
Every one to two weeks, based on your response and provider guidance.
Safety & monitoring
Every session is observed, start to finish
SPRAVATO is available only through the FDA-required SPRAVATO REMS Program. Every session includes monitoring for:
Blood pressure
Sedation
Dissociation
Respiratory effects
Common questions
Frequently asked questions
How quickly does SPRAVATO work?
Some patients report symptom improvement within days, though individual results vary.
Is SPRAVATO the same as ketamine?
SPRAVATO contains esketamine, a specific form of ketamine that has been FDA-approved for certain depression treatments.
Can I drive after treatment?
No. Patients must arrange transportation home and should not drive until the following day after a restful night’s sleep.
Is SPRAVATO covered by insurance?
Many insurance plans provide coverage for eligible patients. Coverage requirements vary by provider.
How long is each appointment?
Most treatment visits require approximately two hours of monitoring after administration.
Who is eligible for SPRAVATO?
Eligibility is determined through a comprehensive psychiatric evaluation by a qualified healthcare provider.
Coverage & access
Insurance & coverage assistance
Benefits verification
We work with many Blue Cross Blue Shield (BCBS), Aetna, Cigna, and UnitedHealthcare/Optum plans for SPRAVATO® treatment. Coverage and authorization requirements vary by individual plan. For appropriate patients, we assist with benefits verification and the prior authorization process before treatment begins.
Already have a psychiatrist, PMHNP, or therapist? You may continue care with your existing provider while receiving SPRAVATO® treatment through our practice.
Prior authorization requests
Eligibility review
Coordination of care
Treatment scheduling
Take the next step toward relief
If depression continues to affect your quality of life despite treatment, additional options may be available. Our psychiatric providers can evaluate whether SPRAVATO® may be appropriate for you.
Or call Telehealth on the Go today at 602-492-2263